Symplocos racemosa plant health benefit, research studies
Symplocos racemosa is an herb used by Ayurvedic doctors for various female disorders.
Symplocos racemosa plant for female
health conditions
Effect of Symplocos racemosa Roxb. on gonadotropin release in immature female
rats and ovarian histology.
J Ethnopharmacol. 2004 September. Bhutani KK, Jadhav AN, Kalia V. Department of
Natural Product, NIPER, Sect. 67, Phase X, SAS Nagar (Mohali) Near Chandigarh,
Punjab 160062, India.
In the present study we are reporting in vivo effect of aqueous extracts of
Symplocos racemosa Roxb. (Fam. Symplocaceae) on serum FSH and LH levels in
immature female Sprague-Dawley rats under basal conditions. Aqueous extract on
oral administration significantly stimulated serum FSH level along with the rise
in serum LH level. Moreover, histopathological studies revealed enhanced
folliculogenesis, presence of mature follicles and detached oocytes, which are
result of increased FSH and LH levels. Further, an increase in the ovary weight
of treated animals was found due to observed FSH surge. These results are in
concordance with the traditional use of Symplocos racemosa for female disorders.
Symplocos racemosa composition
New salirepin derivatives from Symplocos racemosa
J Asian Nat Prod Res. 2007 Apr-Aug; Ahmad VU, Rashid MA, Abbasi MA,
Rasool N, Zubair M. H.E.J. Research Institute of Chemistry, International Centre
for Chemical Sciences, University of Karachi, Karachi 75270, Pakistan.
The phytochemical investigation of the n-butanol soluble fraction of the bark of
stem of Symplocos racemosa Roxb. yielded two new phenolic glycosides of
salirepin series, symplocuronic acid and sympocemoside, while salirepin was
isolated for the first time from this plant.
The bark of stem of Symplocos racemosa Roxb. yielded has phenolic glycosides of salirepin series, symplocuronic acid, sympocemoside, 1-ethyl brachiose-3'-acetate along with ketochaulmoogric acid, nonaeicosanol, triacontyl palmitate, methyl triacontanoate, symplocomoside, symponoside, symplososide, symploveroside. Benzoylsalireposide and salireposide.
An investigation of the kinetic and anti-angiogenic
properties of plant glycoside inhibitors of thymidine phosphorylase.
J Asian Nat Prod Res. 2009; Hussain S, Gaffney J, Ahmed N, Slevin M, Iqbal
Choudhary M, Ahmad VU, Qasmi Z, Abbasi MA. School of Biology, Chemistry and
Health Science, Manchester Metropolitan University, Manchester, UK.
We investigated the potential of symplocomoside (1) and symponoside (2),
glycosides isolated from the bark of Symplocos racemosa to inhibit thymidine
phosphorylase (TP) activity and associated angiogenesis. Compound 1 was a
reversible, noncompetitive inhibitor of deoxythymidine binding to TP and 2 was a
reversible, uncompetitive inhibitor. Molecular modeling analysis indicated that
both compounds bound at the active site of the enzyme but not solely to amino
acid residues involved in catalysis. Both compounds were active in in vitro
angiogenic assays inhibiting endothelial cell migration and invasion in Matrigel,
but did not inhibit growth factor-induced proliferation and were not cytotoxic.
Compound 1 may have potential as an anti-angiogenic and anti-tumor agent.
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